The Scott Christian College enjoys continuity with the school founded in 1809 at Mylaudy by the Rev. William Tobias Ringeltaube, the pioneering missionary of the London Missionary Society in South Travancore. In 1893, it was elevated to a Second Grade College affiliated to the University of Madras with twelve students under Rev. Dr. James Duthie as the first Principal. Rev. Parker built the Science Block for the College in 1908-1910 with a legacy of £1000 from the family of Mr. Septimus Scott and a grant from the government of Travancore. The Library was equipped with up-to-date volumes which ran up to 4000 in 1924.
On February 1, 1927, Mr. G. H. Marsden, M.A Tripos of the University of Cambridge took charge as Principal and took special care in increasing the facilities for the Science Department. By selfless and untiring work, he built up the small Intermediate College of about 140 students. Women students in regular batches were admitted from 1927 onwards. Compulsory games were introduced for the men students in 1927. Scott Christian College became the first Mofussil College in the University of Madras to have compulsory Physical Education for men students under a qualified Physical Director with the status of a Lecturer.
When the University of Travancore was established in 1938, Scott Christian College was admitted to its privileges. The year 1950 saw the introduction of Degree courses at Scott Christian College. The first majors introduced were Mathematics and History, and this was followed by Chemistry (1952), Economics (1954), Physics (1954), Zoology (1956) and Botany (1966). The College was affiliated to the Madurai University in 1966. In 1967, Scott Christian College celebrated its 75th Anniversary as the Platinum Jubilee. The Degree Classes were shifted to the New Campus during 1970 -1971.